Makoto Tominaga Selected Research

TRPV Cation Channels

4/2016	[Thermosensitive TRP channels and brain function].
2/2014	Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury.
4/2011	Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC.
7/2003	Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity.
6/2003	Structural determinant of TRPV1 desensitization interacts with calmodulin.
6/2003	[Molecular mechanisms of nociception].
2/2003	Local inflammation increases vanilloid receptor 1 expression within distinct subgroups of DRG neurons.
4/2002	Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues.

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Makoto Tominaga Research Topics

Disease

41	Pain (Aches) 01/2022 - 04/2002
16	Inflammation (Inflammations) 01/2022 - 02/2003
11	Hyperalgesia 03/2016 - 07/2002
9	Glucose Intolerance 04/2017 - 05/2002
8	Type 2 Diabetes Mellitus (MODY) 10/2014 - 07/2003
5	Diabetes Mellitus 01/2016 - 05/2004
4	Colitis 01/2021 - 01/2018
4	Hypersensitivity (Allergy) 01/2020 - 07/2003
4	Wounds and Injuries (Trauma) 01/2019 - 06/2003
4	Insulin Resistance 03/2008 - 05/2005
4	Hypertension (High Blood Pressure) 10/2007 - 08/2003
3	Acute Pain 05/2015 - 02/2013
3	Coronary Disease (Coronary Heart Disease) 02/2008 - 06/2005
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2022 - 01/2016
2	Hyperparathyroidism 07/2020 - 01/2018
2	Neoplasms (Cancer) 01/2020 - 05/2018
2	Pruritus (Itching) 08/2018 - 01/2017
2	Obesity 11/2017 - 03/2016
2	Hyperthermia 01/2016 - 08/2012
2	Hypothermia 01/2016 - 01/2014
2	Fever (Fevers) 01/2016 - 04/2012
2	Gastroesophageal Reflux (GERD) 12/2015 - 07/2011
2	Hemorrhage 07/2014 - 05/2005
2	Body Weight (Weight, Body) 05/2014 - 03/2006
2	Narcolepsy 05/2014 - 07/2011
2	Neuralgia (Stump Neuralgia) 02/2014 - 01/2013
2	Food Hypersensitivity (Food Allergy) 07/2013 - 12/2011
2	Neurogenic Inflammation 01/2012 - 07/2007
2	Atherosclerosis 02/2008 - 09/2007
2	Diabetic Nephropathies (Diabetic Nephropathy) 08/2006 - 10/2004
1	Endotoxemia 01/2022
1	Cough 01/2022
1	Ischemia 01/2021
1	Colitis-Associated Neoplasms 01/2020
1	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 01/2020
1	Visceral Pain 01/2020
1	Atopic Dermatitis (Atopic Eczema) 03/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Acidosis 01/2019
1	Rhinitis 01/2019
1	Ganglion Cysts (Ganglion) 01/2019

Drug/Important Bio-Agent (IBA)

13	Glucose (Dextrose)FDA LinkGeneric 04/2017 - 05/2002
10	Capsaicin (Zostrix)FDA Link 03/2018 - 06/2003
9	Ion Channels (Ion Channel)IBA 01/2022 - 04/2002
8	TRPV Cation ChannelsIBA 04/2016 - 04/2002
5	Adenosine Triphosphate (ATP)IBA 01/2022 - 06/2003
5	BradykininIBA 01/2022 - 07/2002
5	AnkyrinsIBA 03/2019 - 08/2012
5	Messenger RNA (mRNA)IBA 01/2018 - 04/2010
5	Analgesics (Analgesic Drugs)IBA 01/2018 - 01/2014
4	AcidsIBA 01/2021 - 06/2010
4	CationsIBA 01/2020 - 06/2003
4	Anoctamin-1IBA 07/2019 - 04/2015
4	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 04/2017 - 01/2005
3	Dextrans (Dextran)FDA Link 01/2021 - 01/2018
3	Nerve Growth Factor (NGF)IBA 01/2019 - 09/2005
3	capsazepineIBA 11/2017 - 01/2016
3	Insulin (Novolin)FDA Link 03/2016 - 03/2007
3	Pharmaceutical PreparationsIBA 01/2016 - 08/2012
3	Proteins (Proteins, Gene)FDA Link 02/2014 - 02/2003
3	CholesterolIBA 09/2008 - 08/2003
3	Protons (Proton)IBA 12/2004 - 06/2003
2	Transient Receptor Potential ChannelsIBA 07/2020 - 01/2014
2	SodiumIBA 01/2020 - 01/2018
2	Clodronic Acid (Clodronate)IBA 01/2020 - 08/2018
2	Chloride Channels (Chloride Channel)IBA 07/2019 - 01/2017
2	Calcitonin Gene-Related PeptideIBA 07/2019 - 03/2018
2	lysophosphatidic acidIBA 01/2019 - 01/2017
2	GlucansIBA 08/2018 - 01/2017
2	AntigensIBA 01/2017 - 12/2011
2	Cyclic ADP-Ribose (cADPR)IBA 01/2016 - 05/2006
2	LipidsIBA 01/2016 - 02/2008
2	OrexinsIBA 05/2014 - 07/2011
2	Ammonium Chloride (Sal Ammoniac)FDA Link 03/2010 - 12/2008
2	Pioglitazone (Actos)FDA Link 02/2008 - 09/2007
2	Tryptases (Tryptase)IBA 07/2007 - 05/2004
2	TrypsinIBA 07/2007 - 05/2004
2	AdiponectinIBA 03/2006 - 07/2003
1	EnzymesIBA 01/2022
1	EndotoxinsIBA 01/2022
1	KynurenineIBA 01/2022
1	DioxygenasesIBA 01/2022
1	NAD (NADH)IBA 01/2022
1	sialorphinIBA 01/2022
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2021
1	Serotonin (5 Hydroxytryptamine)IBA 01/2020
1	NucleotidesIBA 01/2020
1	AnionsIBA 07/2019
1	Ointments (Pastes)IBA 03/2019
1	Immunosuppressive Agents (Immunosuppressants)IBA 03/2019
1	Tacrolimus (Prograf)FDA LinkGeneric 03/2019
1	Sulfur Compounds (Compounds, Sulfur)IBA 01/2019
1	SaltsIBA 01/2019
1	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2019
1	Menthol FDA Link 01/2019

Therapy/Procedure

3	Therapeutics 11/2016 - 01/2014
2	Vagotomy 11/2017 - 01/2017
2	Denervation 11/2017 - 01/2017
1	Oral Administration 01/2021
1	Induced Hypothermia 01/2021